Study of Interactions between Monoherbal Formulation of Arjuna and Aloe vera in Isoproterenol Induced Cardiotoxicity Rat Model

Abstract:

Introduction: Arjuna is used for its cardioprotective action while Aloe vera is herbal dietary supplement. Isoproterenol hydrochloride was administered subcutaneously to rats to induce myocardial infarction. Objectives: The given study was conducted to determine any pharmacodynamic interaction between marketed formulations i.e., Arjuna and Aloe vera. Materials and Methods: The varying tissue damage caused by Isoproterenol in different groups was confirmed from electrocardiogram (Heart rate, ST segment elevation time, QRS complex amplitude), levels of serum cardiac markers (creatine kinase, isoform of creatine kinase, Lactate dehydrogenase), blood electrolytes levels, by determining antioxidant enzymes activity (Superoxide dismutase, Catalase, Glutathione) and histopathological results. Results: The interaction group showed increased Heart rate, increased ST segment elevation time, decreased QRS complex; decreased antioxidant enzyme activity and increased levels of cardiac markers when compared to Arjuna group. The results were found to be statistically significant (p<0.05). Conclusion: Detrimental effect was found between two herbal formulations as a result of which the Cardioprotective effect of Arjuna was decreased when administered simultaneously with Aloe vera.

Keywords: Isoproterenol, Aloe vera, Arjuna, Myocardial infarction, Cardiotoxicity.