Antidiabetic Effect of Flower Extract of Antigonon leptopus Hook & Arn in Alloxan-induced Diabetic Rats

Abstract:

The antidiabetic effect of methanolic extract of flowers of Antigonon leptopus (MFAL) was evaluated at three different doses i.e. 100, 200 and 400 mg/kg, p.o. in normal, glucose fed and alloxan-induced diabetic rats. The antihyperglycemic effect of MFAL at 200 mg/kg b.w. was relatively better than that of the other two test doses (100 and 400 mg/kg, b.w.), with respective to the percent reduction of blood glucose level during the entire period of study. In sub acute study (21 days), the antihyperglycemic effect of MFAL at 200 mg/kg b.w. was supported by the reversal of changes occurred in other parameters such as body weight, serum insulin, aspartate transaminase (AST), alanine transaminase (ALT), serum triglycerides, serum cholesterol and serum total proteins, which are implicated in diabetes. Hypoglycemic and antidiabetic effects of the MFAL were found to be well comparable with glibenclamide (10 mg/kg, b.w, p.o.), a reference drug used in type 2 diabetes therapy.

Keywords: Antigonon leptopus, Alloxan, Antidiabetic effect, Glibenclamide.