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Mon, 01/19/2015 - 11:10  |  Anonymous
Published on:19th Jan, 2015
Indian Journal of Pharmaceutical Education Research, 2010; 44(1):8-21
Pharmaceutical Education | doi:Nill

Synthesis and Antimicrobial Activity of Novel 6-Hydroxy-4-oxopyrido[ 2,3-h]quinoline-3[(substituted aryl ureido / piperazinyl) carbonyl] Quinolines


Authors and affiliation (s):

Patel N.B.* and Modi S.H.

Veer Narmad South Gujarat University, Surat-395007, India.

Abstract:

A number of amide derivatives of pyrido quinolone have been synthesized and evaluated potency against gram positive and gram-negative bacteria, Ciprofloxacin and Gatifloxacin is used as standard drug. Compound 6 to 21 showed moderate activities compared to ciprofloxacin and gatifloxacin and compound 22 to 31 showed good activities compared with the standard drugs. The substituted piperazine attached at C-3 as amide, enhanced the activities of pyrido quinolones.

Key words: Ciprofloxacin, pyrido quinoline, microbial activity & potency.

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