Formulation and Evaluation of Orodispersible Liquisolid Compacts of Aceclofenac

Abstract:

Liquisolid compacts were used to formulate water insoluble drugs in non-volatile solvents and converting into acceptably flowing and compressible powders. The objectives of present investigations were formulation and evaluation orodispersible liquisolid compacts of aceclofenac by using different dissolution enhancers and study the effect of way of addition of superdisintegrants on rate dissolution of aceclofenac. Liquisolid compacts of aceclofenac were prepared by dispersing the drug in various dissolution enhancing agents(Propylene glycol, Polyethylene glycol 400 and Tween 80 in 1:1 ratio with drug ), then addition of diluents, superdisintegratns (like Cross carmelose Sodium, Cross povidone and Sodium starch glycolate) in various ways and in combinations finally addition of glidants and lubricants. Before compactions powdered mass were evaluated for flow properties. Compacts were evaluated for disintegration test, weight variation test, in vitro dissolution study, friability Test, wetting time, hardness Test and data was analyzed statistically. All liquisolid compacts being orodispersible rapidly disintegrate within 3 minutes with enhanced dissolution properties over the conventional tablet of aceclofenac. Among all formulations, Tween 80 liquisolid compact containing cross carmelose sodium showed highest dissolution. The combination of superdisintegrants enables us to study the effect of combined disintegrating action on drug release. Among this, compacts with Sodium starch glycolate added intragranularly and cross povidone extra granularly showed highest dissolution rate. Aceclofenac release from tablets followed Peppas model. Orodispersible liquisolid compacts prepared with Tween 80 enhance the dissolution rate of aceclofenac to a greater extent. Hence liquidsolid compacts and way of addition of superdisintegratns is useful technique in enhancement of dissolution rate of aceclofenac.