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Published on:11th Feb, 2015
Indian Journal of Pharmaceutical Research and Education, 2011; 45(2):108-113
Pharmaceutical Education | doi:Nill

Hepatoprotective Efficacy of Swietenia Mahagoni L. Jacq. (Meliaceae) Bark against Paracetamol-induced


Authors and affiliation (s):

Pallab K. Haldar1*, Soumitra Adhikari2 , Samit Bera1 , Sanjib Bhattacharya3, Siva P. Panda1, Chandi C. Kandar2

1Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.

2Institute of Pharmacy, Jalpaiguri, West Bengal, India.

3Bengal School of Technology, Delhi Road, Hooghly, West Bengal, India.

Abstract:

In present study, the defatted methanol extract of Swietenia mahagoni bark (MESM) was evaluated for its protective effect on paracetamolinduced liver damage in Wistar rats. Liver histopathology, serum biochemical parameters viz. serum glutamine oxaloacetate transaminase (SGOT), serum glutamine pyruvate transaminase (SGPT), serum alkaline phosphatase (SALP), total serum protein, total bilirubin content; and liver biochemical parameters such as thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH) content, superoxide dismutase (SOD), catalase (CAT) were estimated. Biochemical and histopathological observations indicated that MESM exerted remarkable hepatoprotective efficacy against paracetamol-induced hepatic damage in rats that is plausibly attributable to its augmenting endogenous antioxidant mechanisms.

KEY WORDS: Lipid peroxidation, Glutathione, Biochemical, Silymarin.

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