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Wed, 02/11/2015 - 06:31  |  Anonymous
Published on:11th Feb, 2015
Indian Journal of Pharmaceutical Research and Education, 2011; 45(2):153-156
Pharmaceutical Education | doi:Nill

A Validated RP-HPLC Method for the Determination of Lornoxicam


Authors and affiliation (s):

 D. Anantha Kumar, S. Tanuja, J.V.L.N. Seshagiri Rao*

Pharmaceutical Analysis and Quality Assurance Division, College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003.

Abstract:

A reverse phase high perfomance liquid chromatographic method was deveoloped for simultaneous determination of lornoxicam in pharmacertucal dosage forms. The separation was effected on a Luna C18 column (250 nmx4.6 nm; 5u)using a mobile phase mixture of potassium dihydrogen phosphate buffer (pH 4.5)and acetonitrile in a ration of 50:50v/v at a flow rate of 1,l/min. The detection was made at 295 lornoxicam. The proposed method was validated as per the ICH guidliness. The method was accurate and precise and found to be suitable for the quantitative analysis of the drug in thablets and injection dosage forms.

KEY WORDS: Lornoxicam, Determination, Tablets, Injections,HPLC.

 




 

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