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Published on:11th Feb, 2015
Indian Journal of Pharmaceutical Research and Education, 2011; 45(2):157-163
Pharmaceutical Education | doi:Nill

Synthesis and Biological Evaluation of Some Novel Phenyl Thiazole Derivatives as Possible Antimicrobial Agents


Authors and affiliation (s):

B.S Kittur 1*, B.S Sastry2, Y. Rajendra Prasad3, S R Pattan4, Y Srinivas5

1Department of Pharmaceutical Chemistry &Pharmacognosy, HSK College of Pharmacy, BVVS Campus Bagalkot. 587101, Karnataka

2Department of Pharmaceutical Chemistry, Medak Institute of Technology-Pharmacy Sy.No: 551, Shangri-la, Kothapet (V), Near Narasapur, Shivampet (M), Medak Dist.

3Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Andhra University Visakhapatnam, Andhra Pradesh

4Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy Loni, Maharastra

5Department of Pharmacognosy, HSK College of Pharmacy, Bagalkot - 587101

Abstract:

A new series of phenyl thiazole derivatives has been synthesized by condensing ortho diketone, substituted aldehydes and aromatic amines. The structures of these compounds were established by spectral data. All the synthesized compounds have been screened for their antitubercular activity against Mycobacterium tuberculosis H37 Rv strain and antimicrobial activity against E.coli, S.aureus, A.niger and 37 C.albicans. Most of the compounds have shown significant antitubercular, antibacterial and antifungal activities when compared with the standard drugs.

KEYWORDS: Phenyl thiazole, Antitubercular, Antibacterial and Antifungal

 




 

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