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Wed, 02/11/2015 - 06:41  |  Anonymous
Published on:11th Feb, 2015
Indian Journal of Pharmaceutical Research and Education, 2011; 45(2):164-167
Pharmaceutical Education | doi:Nill

Synthesis and Biological Evaluation of Some Novel Pyrazolines


Authors and affiliation (s):

B.C.Revanasiddappa*, E.V.S.Subrahmanyam and T.N.Lakshmi

*Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Paneer, Deralakatee-574160, Mangalore, Karnataka, India

Abstract:

A novel series of pyrazolines were synthesized from 2-thiophene carboxaldehyde (I). in ethanol with substituted acetophenones (II) in presence of NaOH yielded corresponding 2- substituted -3-thiophene-2-yl-prop-2-en-1-one (III) which on treatment with hydrazine hydrate in presence of catalytic amount of piperidine yielded 2-substituted-3-thiophene-2-yl-4,5-dihydro-1Hpyrazole( IV). The structures of the final synthesized compounds (IVa-IVi) were established on the basis of IR, H-1NMR, MASS spectral data. The synthesized compounds were screened for antibacterial and antifungal activities. When compared to the antifungal activity, compounds showed very good antibacterial activity.

Keywords: Pyrazoline, Chalcones, Antibacterial, Antifungal.

 




 

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