Formulation Design and Optimization of Sustained Release Tablets of Terbutaline Sulphate

Abstract:

The sustained release matrix tablets of terbutaline Sulphate (TS) was prepared by wet granulation technique using polyvinyl chloride (PVC) and ethylcellulose. Citric acid was used to set up a system which would bring about gradual release of drug. The granules were evaluated for angle of repose, bulk density, compressibility index, and drug content. The tablets were subjected to thickness, diameter, swelling index, weight variation test, drug content, hardness, friability, and in vitro release studies. carried out in phosphate buffer (pH 7.4) for 12 h. All the formulations exhibited Higuchi-dominated drug release. The mechanism of drug release was found to be anomalous. 2 In the present investigation, a 3 full factorial design was used to investigate the joint influence of 2 formulation variables: amount of PVC and Ethyl cellulose (EC). The results of multiple linear regression analysis revealed that for obtaining a sustained dosage form, tablets should be prepared using an optimum concentration of PVC and EC. A contour plot is also presented to graphically represent the effect of the independent variables on the dissolution time.

Keywords: Sustained release tablets, Terbutaline Sulphate, polyvinyl chloride, Ethylcellulose, factorial design, contour plot.