Synthesis and Anticancer Activity of 3, 5-Diaryl 1, 2, 4-Oxadiazole Derivatives

Abstract:

3, 5- diaryl- 1, 2, 4-oxadiazole derivatives are synthesized by condensation reaction of amidoximes with aromatic acid chloride. Amidoximes are obtained from aromatic nitriles and acid chlorides from corresponding aromatic monocarboxylic acid derivatives. There are broad possibilities of preparing several such compounds in this series by using different aromatic nitriles as well as different aromatic monocarboxylic acid derivatives. The synthesized compounds (a-e) were characterized by IR, 1H NMR studies and evaluated for their anticancer activity using mice specific Ehrlich Ascites Carcinoma cell (EAC cells) in Swiss albino mice model. Synthesized compounds (a-e) (dose 25 mg/ kg body weight) show significant reduction of tumor cell count as well as tumor weight, where as life span of the treated mice also increased. The compound (c) showed significant inhibition of cancer cell growth as compared to others. The standard drug used for the study is 5-Fluorouracil ( 20mg/kg body weight).

Keywords- Amidoxime, 1, 2, 4-Oxadiazole, Acid chloride, EAC cells